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Valium (diazepam) is a benzodiazepine derivative. The chemical name of
diazepam is 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin­
2-one. It is a colorless to light yellow crystalline compound, insoluble in
water. The empirical formula is C16H13ClN2O and the molecular weight is
Valium is available for oral administration as tablets containing 2 mg, 5 mg or
10 mg diazepam. In addition to the active ingredient diazepam, each tablet
contains the following inactive ingredients: anhydrous lactose, corn starch,
pregelatinized starch and calcium stearate with the following dyes: 5-mg
tablets contain FD&C Yellow No. 6 and D&C Yellow No. 10; 10-mg tablets
contain FD&C Blue No. 1. Valium 2-mg tablets contain no dye.

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Valium is indicated for the management of anxiety disorders or for the shortterm
relief of the symptoms of anxiety. Anxiety or tension associated with the
stress of everyday life usually does not require treatment with an anxiolytic.
In acute alcohol withdrawal, Valium may be useful in the symptomatic relief
of acute agitation, tremor, impending or acute delirium tremens and
Valium is a useful adjunct for the relief of skeletal muscle spasm due to reflex
spasm to local pathology (such as inflammation of the muscles or joints, or
secondary to trauma), spasticity caused by upper motor neuron disorders (such
as cerebral palsy and paraplegia), athetosis, and stiff-man syndrome.
Oral Valium may be used adjunctively in convulsive disorders, although it has
not proved useful as the sole therapy.
The effectiveness of Valium in long-term use, that is, more than 4 months, has
not been assessed by systematic clinical studies. The physician should
periodically reassess the usefulness of the drug for the individual patient.

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Side effects most commonly reported were drowsiness, fatigue, muscle
weakness, and ataxia. The following have also been reported:
Central Nervous System: confusion, depression, dysarthria, headache, slurred
speech, tremor, vertigo
Gastrointestinal System: constipation, nausea, gastrointestinal disturbances
Special Senses: blurred vision, diplopia, dizziness
Cardiovascular System: hypotension
Psychiatric and Paradoxical Reactions: stimulation, restlessness, acute
hyperexcited states, anxiety, agitation, aggressiveness, irritability, rage,
hallucinations, psychoses, delusions, increased muscle spasticity, insomnia,
sleep disturbances, and nightmares. Inappropriate behavior and other adverse
behavioral effects have been reported when using benzodiazepines. Should
these occur, use of the drug should be discontinued. They are more likely to
occur in children and in the elderly.
Urogenital System: incontinence, changes in libido, urinary retention
Skin and Appendages: skin reactions
Laboratories: elevated transaminases and alkaline phosphatase
Other: changes in salivation, including dry mouth, hypersalivation
Antegrade amnesia may occur using therapeutic dosages, the risk increasing at
higher dosages. Amnestic effects may be associated with inappropriate
Minor changes in EEG patterns, usually low-voltage fast activity, have been
observed in patients during and after Valium therapy and are of no known
Because of isolated reports of neutropenia and jaundice, periodic blood counts
and liver function tests are advisable during long-term therapy.

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Valium is contraindicated in patients with a known hypersensitivity to
diazepam and, because of lack of sufficient clinical experience, in pediatric
patients under 6 months of age. Valium is also contraindicated in patients with
myasthenia gravis, severe respiratory insufficiency, severe hepatic
insufficiency, and sleep apnea syndrome. It may be used in patients with
open-angle glaucoma who are receiving appropriate therapy, but is
contraindicated in acute narrow-angle glaucoma.

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